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List of Figures

1.1 Dopamine
1.2 L(–)-Epinephrine
1.3 L(–)-Norepinephrine
1.4 Autoinhibition of noradrenaline release and feedback loops
1.5 Proposed model for insertion of the β2 receptor in the cell membrane
2.1 Ethidium bromide
2.2 Fluorescent sequencing versus radioactive sequencing
3.1 Methods for the detection (A) and characterisation (B) of point mutations
4.1 Fluorescein/rhodamine dye primers
4.2 dRhodamine terminators
4.3 Emission spectra of dRhodamine dyes
4.4 Age, Body mass index, Diastolic and Systolic blood pressure trends for phase II and phase III of the Caerphilly data set
4.5 Dye Primer sequencing (forward strand) of the Arg/Gly16 (A1309G) mutation
4.6 BigDye Terminator sequencing (reverse strand) of the Arg/Gly16 (A1309G) mutation
4.7 BigDye Terminator sequencing (forward strand) of the Gln/Glu27 (C1342G) mutation
4.8 Scatter diagram of body mass index (kg/m2) against systolic (a) and diastolic (b) blood pressure (mmHg) in phase II of the Caerphilly data set
4.9 ANOVA of the Gln27Gly variant in phase II
4.10 ANOVA of the Gln27Gly variant in phase III
4.11 ANOVA of the 5’ LC-Arg19Cys variant in phase II
4.12 ANOVA of the 5’ LC-Arg19Cys variant in phase III
4.13 ANOVA of the Arg16Gly variant
4.14 ANOVA of the β2 adrenoceptor haplotypes in phase II
4.15 ANOVA of the β2 adrenoceptor haplotypes in phase III
5.1 bMAPa in subjects homozygous for Gly16 and Arg16 allele and in heterozygotes
5.2 ANOVA for BMI
5.3 Alignment of mammalian 5’ LC nucleotide sequence
5.4 Alignment of mammalian β2 adrenoceptor sequence
5.5 Haplotypes of the β2 adrenoceptor
5.6 Polymorphisms of the human β2 adrenoceptor

We have complete confidence that further research, of the intensity recently given to genetics, will eventually provide man with the ability to describe with completeness the essential features that constitute life.

JAMES D. WATSON
The Molecular Biology of the Gene,
Publishing Company, 1976

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© 2001 Alexander Binder