Table A.1: Nucleotide sequence of the human β2-adrenergic
receptor gene
. . . .
1000 GAGGGCAGTTCCCCTAAAGTCCTGTGCACATAAC 1033
. . . . .
GGGCAGAACGCACTGCGAAGCGGCTTCTTCAGAGCACGGGCTGGAAC 1080
. . . .
TGGCAGGCACCGCGAGCCCCTAGCACCCGACAAGCTGAGTGTGCAGG 1127
. . . .
ACGAGTCCCCACCACACCCACACCACAGCCGCTGA ATG AGG CTT 1171
Met Arg Leu 3
CCA GGC GTC CGC TCG CGG CCC GCA GAG CCC CGC CGT 1207
Pro Gly Val Arg Ser Arg Pro Ala Glu Pro Arg Arg 15
C . . C
GGG TCC GCC TGC TGA GGCGCCCCCAGCCAGTGCGCTTACCTG 1249
Gly Ser Ala Cys End 19
Arg
. .
CCAGACTGCGCGCC ATG GGG CAA CCC GGG AAC GGC AGC 1287
Met Gly Gln Pro Gly Asn Gly Ser 8
A
GCC TTC TTG CTG GCA CCC AAT GGA AGC CAT GCG CCG 1323
Ala Phe Leu Leu Ala Pro Asn Gly Ser His Ala Pro 20
Arg
G
GAC CAC GAC GTC ACG CAG CAA AGG GAC GAG GTG TGG 1359
Asp His Asp Val Thr Gln Gln Arg Asp Glu Val Trp 32
Glu
Nucleotide sequence of the human β2-adrenergic receptor gene (cont.)
A
GTG GTG GGC ATG GGC ATC GTC ATG TCT CTC ATC GTC 1395
Val Val Gly Met Gly Ile Val Met Ser Leu Ile Val 44
Met
CTG GCC ATC GTG TTT GGC AAT GTG CTG GTC ATC ACA 1431
Leu Ala Ile Val Phe Gly Asn Val Leu Val Ile Thr 56
GCC ATT GCC AAG TTC GAG CGT CTG CAG ACG GTC ACC 1467
Ala Ile Ala Lys Phe Glu Arg Leu Gln Thr Val Thr 68
AAC TAC TTC ATC ACT TCA CTG GCC TGT GCT GAT CTG 1503
Asn Tyr Phe Ile Thr Ser Leu Ala Cys Ala Asp Leu 80
G
GTC ATG GGC CTA GCA GTG GTG CCC TTT GGG GCC GCC 1539
Val Met Gly Leu Ala Val Val Pro Phe Gly Ala Ala 92
CAT ATT CTT ATG AAA ATG TGG ACT TTT GGC AAC TTC 1575
His Ile Leu Met Lys Met Trp Thr Phe Gly Asn Phe 104
TGG TGC GAG TTT TGG ACT TCC ATT GAT GTG CTG TGC 1611
Trp Cys Glu Phe Trp Thr Ser Ile Asp Val Leu Cys 116
GTC ACG GCC AGC ATT GAG ACC CTG TGC GTG ATC GCA 1647
Val Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala 128
GTG GAT CGC TAC TTT GCC ATT ACT TCA CCT TTC AAG 1683
Val Asp Arg Tyr Phe Ala Ile Thr Ser Pro Phe Lys 140
TAC CAG AGC CTG CTG ACC AAG AAT AAG GCC CGG GTG 1719
Tyr Gln Ser Leu Leu Thr Lys Asn Lys Ala Arg Val 152
T
ATC ATT CTG ATG GTG TGG ATT GTG TCA GGC CTT ACC 1755
Ile Ile Leu Met Val Trp Ile Val Ser Gly Leu Thr 164
Ile
Nucleotide sequence of the human β2-adrenergic receptor gene (cont.)
C
TCC TTC TTG CCC ATT CAG ATG CAC TGG TAC AGG GCC 1791
Ser Phe Leu Pro Ile Gln Met His Trp Tyr Arg Ala 176
ACC CAC CAG GAA GCC ATC AAC TGC TAT GCC AAT GAG 1827
Thr His Gln Glu Ala Ile Asn Cys Tyr Ala Asn Glu 188
ACC TGC TGT GAC TTC TTC ACG AAC CAA GCC TAT GCC 1863
Thr Cys Cys Asp Phe Phe Thr Asn Gln Ala Tyr Ala 200
ATT GCC TCT TCC ATC GTG TCC TTC TAC GTT CCC CTG 1899
Ile Ala Ser Ser Ile Val Ser Phe Tyr Val Pro Leu 212
GTG ATC ATG GTC TTC GTC TAC TCC AGG GTC TTT CAG 1935
Val Ile Met Val Phe Val Tyr Ser Arg Val Phe Gln 224
GAG GCC AAA AGG CAG CTC CAG AAG ATT GAC AAA TCT 1971
Glu Ala Lys Arg Gln Leu Gln Lys Ile Asp Lys Ser 236
GAG GGC CGC TTC CAT GTC CAG AAC CTT AGC CAG GTG 2007
Glu Gly Arg Phe His Val Gln Asn Leu Ser Gln Val 248
GAG CAG GAT GGG CGG ACG GGG CAT GGA CTC CGC AGA 2043
Glu Gln Asp Gly Arg Thr Gly His Gly Leu Arg Arg 260
TCT TCC AAG TTC TGC TTG AAG GAG CAC AAA GCC CTC 2079
Ser Ser Lys Phe Cys Leu Lys Glu His Lys Ala Leu 272
AAG ACG TTA GGC ATC ATC ATG GGC ACT TTC ACC CTC 2115
Lys Thr Leu Gly Ile Ile Met Gly Thr Phe Thr Leu 284
TGC TGG CTG CCC TTC TTC ATC GTT AAC ATT GTG CAT 2151
Cys Trp Leu Pro Phe Phe Ile Val Asn Ile Val His 296
GTG ATC CAG GAT AAC CTC ATC CGT AAG GAA GTT TAC 2187
Val Ile Gln Asp Asn Leu Ile Arg Lys Glu Val Tyr 308
ATC CTC CTA AAT TGG ATA GGC TAT GTC AAT TCT GGT 2223
Ile Leu Leu Asn Trp Ile Gly Tyr Val Asn Ser Gly 320
TTC AAT CCC CTT ATC TAC TGC CGG AGC CCA GAT TTC 2259
Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe 332
AGG ATT GCC TTC CAG GAG CTT CTG TGC CTG CGC AGG 2295
Arg Ile Ala Phe Gln Glu Leu Leu Cys Leu Arg Arg 344
G
TCT TCT TTG AAG GCC TAT GGC AAT GGC TAC TCC AGC 2331
Ser Ser Leu Lys Ala Tyr Gly Asn Gly Tyr Ser Ser 356
AAC GGC AAC ACA GGG GAG CAG AGT GGA TAT CAC GTG 2367
Asn Gly Asn Thr Gly Glu Gln Ser Gly Tyr His Val 368
GAA CAG GAG AAA GAA AAT AAA CTG CTG TGT GAA GAC 2403
Glu Gln Glu Lys Glu Asn Lys Leu Leu Cys Glu Asp 380
CTC CCA GGC ACG GAA GAC TTT GTG GGC CAT CAA GGT 2439
Leu Pro Gly Thr Glu Asp Phe Val Gly His Gln Gly 392
ACT GTG CCT AGC GAT AAC ATT GAT TCA CAA GGG AGG 2475
Thr Val Pro Ser Asp Asn Ile Asp Ser Gln Gly Arg 404
G .
AAT TGT AGT ACA AAT GAC TCA CTG CTA TAA AGCAGTT 2512
Asn Cys Ser Thr Asn Asp Ser Leu Leu End 413
. . . . .
TTTCTACTTTTAAAGACCCCCCCCCGCCCAACAGAACACTAAACAGAC 2560
. . . .
TATTTAACTTGAGGGTAATAAACTTAGAATAAAATTGTAA 2600
Table A.1: Nucleotide and deduced amino acid sequence of the human
β2-adrenergic receptor gene (cont.). Nucleotide numbers are to the right of the
sequence. Amino acid numbers are below the nucleotide numbers. Mutations
are denoted above the nucleotide sequence. Amino acids are represented using
the three-letter code.
© 2001 Alexander Binder