Adrenoceptor Alleles in Relation to Adrenoceptor Expression in Cultured Skin Fibroblasts

adrenoceptor density ranged from 5 to 298 fmol/mg (median 101 fmol/mg). The C G nucleotide exchange did have no impact on adrenergic receptor density. There was a tendency towards lower adrenoceptor densities in fibroblasts derived from subjects with AA as compared to GG genotypes. The frequency of A in fibroblast cultures with adrenoceptor densities < 100 fmol/mg was 0.125 (0.049-0.268, 95% confidence interval) as compared to the group with adrenoceptor densities above the median, which showed a A frequency of 0.278 (0.142-0.452, 95% confidence interval, p=0.09).