Candidate genes are selected from systems physiologically implicated in blood pressure regulation, e. g. the adrenergic receptor genes. Ideally, it may be possible to demonstrate biochemical or functional differences in the gene product which track with blood pressure through families, and also to identify genetic variations that associates with the trait. Several mutations have been identified within the β2 adrenergic receptor which may contribute to the development of elevated blood pressure, and which may influence therapeutic response to blood pressure-lowering therapy.
In this thesis the β2 adrenergic receptor gene was utilised as a candidate gene in several association studies.
© 2001 Alexander Binder