This work started with the discovery of some new mutations of the b2-adrenoceptor, the development of a screening system for different receptor alleles and an association study of the b2 genotypes with salt-sensitivity. This study has made up my Master's Thesis and is available online as well (you may download this as PDF document as well).
The last few years I'm trying to do association and linkage studies on the b2-adrenoceptor and hypertension. As several mutations on the receptor gene show differences in their physiological behaviour, we do complete sequencing of the gene, using direct sequencing on an ABI377. Most of this work (and a few other studies in progress) is done in cooperation with the Department of Clinical Pharmacology, Queen Mary College (University of London), and St. Bartholomew's Hospital, London. That's the reason you find a message stating I am at St. Bart's Hospital on my homepage quite often. My London address is available as well.
For a start, I've put the essentials on adrenergic receptors here. A list of publications is available as well.
Since the end of 2003, I am working on a new fascinating project on meningococcal disease
and its connection to genetic polymorphisms. This project has already lead to interesting
results, which will be published this summer. Even better, I will adress some other
issues of this topic later this year, which hopefully will lead to some fruitful
cooperations with other groups as well. More information on meningococcal disease and the
topics I'm interested in will be available here later this year.